Hematopoietic Progenitor Cells (HPCs) from Peripheral Blood

Facilities requesting collection of HPCs from peripheral blood by apheresis should contact the Clinical Apheresis Department. Clinical Apheresis will coordinate scheduling with the Carter BloodCare Cell Therapy Laboratory, if necessary. A written physician order for collection and processing, including endpoint of collection is required prior to initiation of procedures. Consent to process, freeze and store HPCs is required.

Prior to each HPC collection, the institution must perform administration of G-CSF, catheter placement (when appropriate) and appropriate reports documenting clearance for use. In addition, a Complete Blood Count (CBC) including differential count must be performed before collection.

Carter BloodCare requires a letter of donor suitability, provided by the donor’s physician. The letter must state that the donor has been evaluated by medical history, physical exam and laboratory tests for the risk of apheresis donation. In addition, when appropriate, documentation of a pregnancy assessment on all female donors is required. Physicians must provide written prescription authorizing collection for a specific time period.

Donor Prescreen for HPC Collection

Carter BloodCare works closely with clients throughout the prescreening process. Agreements to process, freeze and store hematopoietic cells must exist between the requesting facility, Carter BloodCare and the donor.

All donors must undergo a prescreening process within 30 days prior to the start of the first collection. The prescreen process includes evaluation of peripheral access, pregnancy assessment for female donor, and consent for release of medical information. Pregnancy assessments must be performed before hematopoietic growth factor administration or myeloablative therapy of the recipient.

All allogeneic donors must complete the donor questionnaire and undergo routine testing for infectious diseases, ABO/Rh typing, and a red cell antibody screen. The allogeneic donor sample is tested with recipient blood for compatibility.

Collection & Submission of HPCs

HOC collection services are available for autologous and allogeneic, adult and pediatric donors. HPC collection may be performed at an outside facility or a predetermined Carter BloodCare Neighborhood Donor Center.

HPC collection is done by trained personnel using apheresis cell separators. Donation of HPC is generally performed as an outpatient procedure and requires adequate preplanning. Autologous donors generally receive placement of a central venous catheter that can accommodate high volume flow rates, typically either a Quinton or a similar dialysis-type catheter.

For healthy allogeneic donors, central line placement may or may not be necessary depending on the donor’s peripheral access, desired flow rates, and number of procedures required.

Peripheral

Peripheral Blood Stem Cells (PBSC) collection services are done by trained personnel using apheresis
cell separators

Processing

Carter BloodCare has expertise in processing autologous and allogeneic PBSCs and bone marrow when a major or minor ABO incompatibility exists

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